The Activity of Thalamic Nucleus Reuniens Is Critical for Memory Retrieval, but Not Essential for the Early Phase of 'Off-Line' Consolidation
In: Learning & Memory, Jg. 25 (2018-03-01), Heft 3, S. 129-137
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Zugriff:
Spatial navigation depends on the hippocampal function, but also requires bidirectional interactions between the hippocampus (HPC) and the prefrontal cortex (PFC). The cross-regional communication is typically regulated by critical nodes of a distributed brain network. The thalamic nucleus reuniens (RE) is reciprocally connected to both HPC and PFC and may coordinate the information flow within the HPC-PFC pathway. Here we examined if RE activity contributes to the spatial memory consolidation. Rats were trained to find reward following a complex trajectory on a crossword-like maze. Immediately after each of the five daily learning sessions the RE was reversibly inactivated by local injection of muscimol. The post-training RE inactivation affected neither the spatial task acquisition nor the memory retention, which was tested after a 20-d "forgetting" period. In contrast, the RE inactivation in well-trained rats prior to the maze exposure impaired the task performance without affecting locomotion or appetitive motivation. Our results support the role of the RE in memory retrieval and/or "online" processing of spatial information, but do not provide evidence for its engagement in "off-line" processing, at least within a time window immediately following learning experience.
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The Activity of Thalamic Nucleus Reuniens Is Critical for Memory Retrieval, but Not Essential for the Early Phase of 'Off-Line' Consolidation
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Autor/in / Beteiligte Person: | Mei, Hao ; Logothetis, Nikos K. ; Eschenko, Oxana |
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Zeitschrift: | Learning & Memory, Jg. 25 (2018-03-01), Heft 3, S. 129-137 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 1072-0502 (print) |
DOI: | 10.1101/lm.047134.117 |
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