Effect of the essential oil of Achillea millefolium L. in the production of hydrogen peroxide and tumor necrosis factor-alpha in murine macrophages

Lopes, Flávia Cristine Mascia ; Benzatti, Fernanda Paulin ; et al.

In: Revista Brasileira de Ciências Farmacêuticas, Jg. 41 (2005-09-01), Heft 3

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Zugriff:

Macrophages release more than one hundred compounds into the extracellular environment. Among these, there are cytokines and intermediate oxygen compounds, such as TNF-alpha and H2O2. We evaluated the effect of the crude essential oil of Achillea millefolium L. (Asteraceae) by determining hydrogen peroxide (H2O2) and tumor necrosis factor-alpha (TNF-alpha) release in cultures of peritoneal macrophages cells from Swiss mice. Commercial azulene was also tested for comparison with the essential oil. The macrophages viability in the presence of the oil was analyzed and the dilutions of 1:100 and 1:200 showed the best results. A mild production of H2O2 and a moderate liberation of TNF-alpha were observed. It was also noticed that H2O2 and TNF-alpha production using commercial azulene was higher than that produced by the oil. The essential oil of A. millefolium was able to stimulate peritoneal macrophages to produce H2O2 and TNF-alpha without causing an overproduction of these compounds. It is suggested that the essential oil can modulate macrophages activation.

Titel:	Effect of the essential oil of Achillea millefolium L. in the production of hydrogen peroxide and tumor necrosis factor-alpha in murine macrophages
Autor/in / Beteiligte Person:	Lopes, Flávia Cristine Mascia ; Benzatti, Fernanda Paulin ; Jordão Junior, Cleso Mendonça ; Moreira, Raquel Regina Duarte ; Carlos, Iracilda Zeppone
Link:	View full text in SciELO (Volltext)
Zeitschrift:	Revista Brasileira de Ciências Farmacêuticas, Jg. 41 (2005-09-01), Heft 3
Veröffentlichung:	Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2005
Medientyp:	academicJournal
ISSN:	1516-9332 (print)
DOI:	10.1590/S1516-93322005000300014
Schlagwort:	Achillea millefolium Macrophages Hydrogen peroxide Tumor necrosis factor-alpha Essential oil
Sonstiges:	Nachgewiesen in: SciELO Sprachen: English Document Type: article File Description: text/html Language: English Rights: info:eu-repo/semantics/openAccess

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