The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
In: Life Science Alliance, Jg. 4 (2021-05-01), Heft 5
Online
academicJournal
- e201900490
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
Titel: |
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
|
---|---|
Autor/in / Beteiligte Person: | Zacarías-Fluck, Mariano F ; Jauset, Toni ; Martínez-Martín, Sandra ; Kaur, Jastrinjan ; Casacuberta-Serra, Sílvia ; Massó-Vallés, Daniel ; del Pozo, Erika Serrano ; Martín-Fernández, Génesis ; González-Larreategui, Íñigo ; López-Estévez, Sergio ; Brown-Swigart, Lamorna ; Beaulieu, Marie-Eve ; Whitfield, Jonathan R ; Madan, Babita ; Virshup, David M ; Evan, Gerard I ; Soucek, Laura |
Link: | |
Zeitschrift: | Life Science Alliance, Jg. 4 (2021-05-01), Heft 5 |
Veröffentlichung: | eScholarship, University of California, 2021 |
Medientyp: | academicJournal |
Umfang: | e201900490 |
Schlagwort: |
|
Sonstiges: |
|