Essential and Non-essential Metals Carcinogenesis, Prevention and Cancer Therapeutics
Cham: Springer International Publishing, 2017
Online
Buch
- 1 Online-Ressource (235 pages)
Zugriff:
Preface -- Acknowledgements -- Contents -- Contributors -- Chapter 1: Calcium Channels and Pumps: Importance During Lactation as Potential Targets for Breast Cancer -- 1.1 Introduction -- 1.2 Ca2+ Transport Mechanisms in Epithelial Cells -- 1.3 Lactation -- 1.4 Ca2+ Transport During Lactation -- 1.4.1 Basolateral Ca2+ Influx in Mammary Epithelial Cells During Lactation -- 1.4.2 Ca2+ Secretion from Mammary Epithelial Cells During Lactation -- 1.4.3 Ca2+ Efflux from Mammary Epithelial Cells During Lactation -- 1.5 Breast Cancer -- 1.6 Ca2+ Signaling and Transport and Breast Cancer -- 1.6.1 ORAI1 and Breast Cancer -- 1.6.2 SPCA2 and Breast Cancer -- 1.6.3 PMCA2 and Breast Cancer -- 1.7 Summary -- References -- Chapter 2: Tumor Development Through the Mg2+nifying Glass -- 2.1 Introduction -- 2.2 Magnesium and Carcinogenesis -- 2.3 Magnesium and Primary Tumor Growth -- 2.4 Magnesium and Tumor Metastasis -- 2.5 Magnesium and Cancer Therapy -- 2.6 Involvement of the TRPM7 Cation Channel -- 2.7 Conclusion -- References -- Chapter 3: Selenium: Roles in Cancer Prevention and Therapies -- 3.1 Selenium Is an Essential Element for Animals, and Selenium Deficiency Is Associated with Multiple Diseases -- 3.2 Naturally Occurring Selenium Compounds in Diet and Selenium in Supplements -- 3.3 Cellular Metabolism of Selenium: Transport, Incorporation, Methylation, and Glutathiolation -- 3.3.1 Selenium Uptake -- 3.3.2 Incorporation to Selenoproteins -- 3.3.3 Reduction and Conjugation of Selenium with GSH -- 3.3.4 Methylation of Selenium -- 3.4 Selenoproteins and Their Expression and Function in Cancers -- 3.4.1 Selenoprotein Cellular Function -- 3.4.2 Roles of Selenoproteins in Cancer -- 3.5 Association of Selenium Level/Selenoprotein SNPs with Cancer Pathologies -- 3.6 Clinical Application of Small Selenium Compounds in Cancer Prevention and Treatment
3.6.1 Selenium Compounds Applied in Cancer Prevention and Treatment as Antioxidant -- 3.6.2 Small-Molecule Selenium Compounds Used in Cancer Prevention and Therapies -- 3.7 Regulation of Oncology Signals by Selenium Compounds -- 3.7.1 Inorganic Selenite Signaling -- 3.7.2 Selenomethione (SeMet) Action in Cancer Cells -- 3.7.3 Se-Methyl-selenocysteine (Se-MSC) Action in Cancer Cells -- 3.7.4 Methylseleninic Acid (MSA) Action in Cancer Cells -- 3.8 Perspectives: Future of Selenium Application in Cancer -- References -- Chapter 4: Zinc and Zinc-Dependent Proteins in Cancer and Chemotherapeutics -- 4.1 Introduction -- 4.2 Zn Homeostasis and Dysregulation -- 4.2.1 Zn Transporters -- 4.2.2 Metallothionein -- 4.2.3 Role of Zn Homeostasis in Chemotherapeutics -- 4.3 Proteins Containing Catalytic Zn -- 4.3.1 Matrix Metalloproteinases -- 4.3.2 Lysine Deacetylases -- 4.4 Proteins Containing Structural Zn -- 4.4.1 Zn Finger Proteins -- Specificity Protein 1 -- Snail Homolog 1 -- Glioma-Associated Oncogene -- 4.4.2 p53 -- 4.5 Summary -- References -- Chapter 5: Arsenic Carcinogenesis -- 5.1 Introduction -- 5.2 Cancer Epidemiology -- 5.2.1 Skin Cancers -- 5.2.2 Lung Cancer -- 5.2.3 Urinary Bladder and Kidney Cancer -- 5.2.4 Liver and Prostate Cancers -- 5.3 Arsenic Carcinogenesis in Laboratory Animals -- 5.4 Cell Proliferation/Stem Cells -- 5.5 DNA Repair/Co-mutagenesis -- 5.6 Aneuploidy/Clastogenesis -- 5.7 Epigenetics -- 5.7.1 DNA Methylation -- 5.7.2 Histone Modification -- 5.7.3 miRNA -- 5.8 Conclusions -- References -- Chapter 6: Cadmium Carcinogenesis and Mechanistic Insights -- 6.1 Introduction -- 6.2 Lung Cancer -- 6.2.1 DNA Repair -- 6.2.2 Apoptosis/Autophagy -- 6.2.3 EGF Receptor (EGFR) and Cell Cycle Regulatory Genes in Cadmium-Induced Lung Cancers -- 6.3 Renal Cancer -- 6.3.1 Cadmium Uptake by Kidneys
6.3.2 Apoptosis, Necrosis, and Autophagy in Proximal Tubule Epithelial Cells -- 6.3.3 Cell Survival Response -- 6.3.4 Notch1, Wnt/β-Catenin, and E-Cadherin-Mediated Cell Signaling in Cadmium-Exposed Renal Proximal Cells and Carcinogenesis -- 6.4 Prostate Cancer -- 6.4.1 Cell Transformation Studies -- 6.5 Breast Cancer -- 6.5.1 Estrogen and Estrogen Receptor -- 6.5.2 E-Cadherin, β-Catenin, and Associated Signaling Events -- 6.6 Pancreatic Cancer -- 6.7 General Molecular Pathways of Cadmium-Mediated Carcinogenesis -- 6.7.1 Oxidative Stress -- 6.7.2 DNA Damage Repair Pathways -- 6.7.3 Aberrant Gene Expression, Transcription, and Translation -- 6.7.4 Transcriptional and Translational Alterations -- 6.7.5 Cell Proliferation and Cycle Regulation -- 6.7.6 Cadmium: Apoptosis and Autophagy in Carcinogenesis -- 6.7.7 Epigenetics -- 6.8 Conclusions and Perspectives -- References -- Chapter 7: Molecular Mechanisms of Chromium-Induced Carcinogenesis -- 7.1 Chromium: History, Production, and Uses -- 7.2 Cr Exposure and Evidence of Carcinogenesis -- 7.3 The Role of Physicochemical Properties in Cr-Induced Carcinogenesis -- 7.4 Characteristics of Cr-Induced Lung Tumors -- 7.5 Potential Mechanisms of Cr(VI)-Induced Carcinogenesis -- 7.5.1 Multistage Carcinogenesis -- 7.5.2 Genomic Instability -- 7.5.3 Epigenetic Modification -- 7.6 Mechanism of Cr(VI)-Induced Carcinogenesis -- References -- Chapter 8: Mechanisms of Nickel Carcinogenesis -- 8.1 Introduction to Nickel -- 8.2 Overview of Cancer -- 8.3 Modes of Carcinogenesis -- 8.4 Environmental Exposure -- 8.5 Epidemiological Investigations -- 8.6 Animal Bioassays -- 8.7 In Vitro Investigations -- 8.8 Genetic Mechanisms Underlying Nickel Carcinogenesis -- 8.9 Epigenetic Mechanisms -- 8.9.1 Acetylation -- 8.9.2 MicroRNA -- 8.10 Conclusion -- References
Chapter 9: Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-Based Drugs -- 9.1 Introduction -- 9.2 Metallomics and Metalloproteomics: The Role in Metallodrug Research -- 9.2.1 Definition and Research Subjects in Metallomics -- 9.2.2 Metalloproteomics -- 9.3 The Technical Platform in Metallomics and Metalloproteomics -- 9.3.1 Chemical Speciation of Bioactive Metallome -- 9.3.2 Metalloproteome Separation and Identification -- 9.4 Biotransformation, Cellular Distribution, and Molecular Targets of Pt-and Ru-Based Anticancer Drugs/Agents -- 9.4.1 Platinum -- 9.4.2 Ruthenium -- 9.5 Multi-targeted Bi-Based Antimicrobial Drugs -- 9.6 Cytotoxicity of Metallic Nanoparticles -- 9.7 Conclusion and Perspective -- References -- Index