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Mesenchymal stem cells (MSCs), a type of adult stem cells, have attracted the attention of scientists and physicians alike due to their unique biological properties and potential for disease treatment. As stem cell research is complex and progressing rapidly, it is important that the experts in this field share their views and perspectives. This book, co-edited by leading global researchers, is divided into three major sections and covers a broad range of topics concerning MSCs during their transition from benchside to bedside. The book is intended for researchers and clinicians in the field o

Titel:	Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation
Autor/in / Beteiligte Person:	Zhao, Robert Chunhua
Link:	zum GVK-Katalog (Volltext) https://swbplus.bsz-bw.de/bsz38684061xcov.jpg http://www.bibliothek.uni-regensburg.de/dbinfo/frontdoor.php?titel_id=7893&bibid=SUBGO http://49gbv-uob-primo.hosted.exlibrisgroup.com/openurl/49GBV_UOB/UOB_services_page?u.ignore_date_coverage=true&rft.mms_id=991016133428003501 http://www.redi-bw.de/start/unifr/EBooks-springer/10.1007/978-94-007-6716-4
Reihe:	SpringerLink Bücher
Veröffentlichung:	Dordrecht: Springer, 2013
Medientyp:	Buch
Umfang:	Online-Ressource (VIII, 313 p. 21 illus., 18 illus. in color, digital)
ISBN:	978-94-007-6716-4 (print) ; 978-94-007-6715-7 (print)
DOI:	10.1007/978-94-007-6716-4
Schlagwort:	Aufsatzsammlung Life sciences Internal medicine Pathology Cytology Stem cells Life Sciences Mesenchymal Stromal Cells
Sonstiges:	Nachgewiesen in: K10plus Sprachen: English Contents Note: Preface; Contents; Part I: Basic Research/Mechanisms; A Historical Overview and Concepts of Mesenchymal Stem Cells; Introduction; Definition, Sources and Types of Mesenchymal Stem Cells; Developmental Origin of MSCs; MSC Plasticity; Immunomodulatory Properties of MSCs; MSC Homing; MSC Secreting Bioactive Molecules; Clinical Applications of MSCs; Conclusions and Future Prospects; References; Biology of MSCs Isolated from Different Tissues; Bone Marrow-Derived MSCs; Adipose Tissue-Derived MSCs; MSCs Derived from Synovial Membrane Tissues; Dental Tissues as Sources of MSC-Like Cells -- Tendon-Derived Stem/Progenitor CellsMSCs Derived from Birth-Associated Tissues; References; Secretome of Mesenchymal Stem Cells; Introduction; Transplantation of MSCs Provides Promising Therapeutic Potential for Tissue Repair and Regeneration; Mechanisms for the Therapeutic Effects of MSCs; Paracrine Mechanisms as a Major Mode of Action for the Therapeutic Effects of MSCs; Secretion of Paracrine Factors in MSCs; Possible Signaling Pathways Involved in the Secretion of Paracrine Factors in MSCs; Role of Akt Signaling in the Expression of Paracrine Factors -- STAT-3 Signaling Is Important in the Expression of VEGF and TGF-β1 in MSCsActivation of p38 MAPK Signaling Is Involved in the Expression of Paracrine Factors in MSCs; Role of TNF Receptor-Mediated Mechanism in the Expression of Paracrine Factors in MSCs; Important Factors Associated with the Paracrine Function in MSCs; Different Paracrine Factors Are Produced in MSCs from Different Species; Age Plays an Important Role in the Expression of Paracrine Factors in MSCs; Gender Is an Important Determinant in the Production of Paracrine Factors in MSCs -- Role of Environmental Factors and Disease States in the Expression of Paracrine Factors in MSCsConclusion and Future Directions; References; Immunomodulatory Properties of Mesenchymal Stem Cells and Related Applications; Introduction; Characteristics of MSC; MSCs Exert Their Immunomodulation Function by Different Mechanisms; The Interaction Between MSCs and T Cells; The Interactions Between MSCs and Antigen-Presenting Cells; The Interaction Between MSCs and B-Cells; Interaction Between MSCs and Natural Killer Cells; MSCs Survive and Induce Immune Tolerance in the Host; Applications of MSCs -- GVHDOrgan Transplantation; Chronic Inflammatory Autoimmune Diseases; Conclusions and Future Directions; References; Mesenchymal Stem Cell Homing to Injured Tissues; Introduction; Homing Capacity of MSCs; Homing Ability of MSCs and Their Therapeutic Effects; Mechanisms of Leukocyte Trafficking into Sites of Inflammation; Potential Ligands/Receptors for MSC Homing; Chemokines for MSC Homing; CCR1 and CCR2 in MSC Homing; CXCR4/SDF-1 Axis in MSC Homing; Other Chemokines; Summary and Prospective; References -- Major Signaling Pathways Regulating the Proliferation and Differentiation of Mesenchymal Stem Cells Document Type: Non-fiction File Description: Text Language: English

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Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation