Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human monocytes to ionizing radiation
In: Frontiers in Immunology, Jg. 14 (2023-12-01)
Online
academicJournal
Zugriff:
Circulating monocytes are important players of the inflammatory response to ionizing radiation (IR). These IR-resistant immune cells migrate to radiation-damaged tissues and differentiate into macrophages that phagocytize dying cells, but also facilitate inflammation. Besides the effect of damage-associated molecular patterns, released from irradiated tissues, the inflammatory activation of monocytes and macrophages is largely dependent on IR-induced DNA damage and aberrant transcriptional activity, which may facilitate expression of type I interferons (IFN-I) and numerous inflammation-related genes. We analyzed the accumulation of dsRNA, dsDNA fragments, and RNA:DNA hybrids in the context of induction of RNA-triggered MAVS-mediated and DNA-triggered STING-mediated signaling pathways, in primary human monocytes and a monocytic cell line, THP1, in response to various doses of gamma IR. We found that exposure to lower doses (
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Cellular RNA and DNA sensing pathways are essential for the dose-dependent response of human monocytes to ionizing radiation
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Autor/in / Beteiligte Person: | Mikhalkevich, Natallia ; Russ, Eric ; Iordanskiy, Sergey |
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Zeitschrift: | Frontiers in Immunology, Jg. 14 (2023-12-01) |
Veröffentlichung: | Frontiers Media S.A., 2023 |
Medientyp: | academicJournal |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2023.1235936 |
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