Ducrosia ismaelis Asch. essential oil: chemical composition profile and anticancer, antimicrobial and antioxidant potential assessment
In: Open Chemistry, Jg. 18 (2020), Heft 1, S. 175-184
Online
academicJournal
Zugriff:
The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty constituents were characterized, representing 96.1% of the total oil. The D. ismaelis essential oil (DIEO) was distinguished by a high composition of oxygenated monoterpenes (51.6%). Decanal (40.6%), α-pinene (15.1%) and dodecanal (13.7%) were the fundamental components. Additionally, DIEO was evaluated for its cytotoxic, antibacterial, antifungal and antioxidant activities. DIEO revealed a great cytotoxic effectiveness against the tested cancer cell lines with IC50 values between 66.2 and 137.3 μg/mL particularly against MCF-7 cancer cells. Furthermore, the induction of apoptosis against MCF-7 cells has been asserted using staining assay (annexin VFITC and/or propidium iodide (PI) dyes) and flow cytometry technique. The DIEO possessed a strong antimicrobial activity against Gram-positive bacterial and fungal strains with MIC-values between 0.07 and 0.31 mg/ml. The values of MBC or MFC were almost once higher than those of MIC’s. Moreover, the β-carotene-bleaching and DPPH free radical-scavenging tests showed that DIEO had a moderate activity (68%) as an antioxidant agent in decolouring of the β-carotene at 1.0 mg/mL and a moderate radical scavenging for DPPH (66 and 72%) at 0.50 and 1.0 mg/mL.
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Ducrosia ismaelis Asch. essential oil: chemical composition profile and anticancer, antimicrobial and antioxidant potential assessment
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Autor/in / Beteiligte Person: | Mothana Ramzi A. ; Nasr Fahd A. ; Khaled Jamal M. ; Noman Omar M. ; Nael, Abutaha ; Al-Rehaily Adnan J. ; Almarfadi Omar M. ; Mine, Kurkcuoglu |
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Zeitschrift: | Open Chemistry, Jg. 18 (2020), Heft 1, S. 175-184 |
Veröffentlichung: | De Gruyter, 2020 |
Medientyp: | academicJournal |
ISSN: | 2391-5420 (print) |
DOI: | 10.1515/chem-2020-0019 |
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