In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
In: Química Nova, Jg. 35 (2012), Heft 4, S. 743-747
Online
academicJournal
Zugriff:
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
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In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
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Autor/in / Beteiligte Person: | Sartorelli, Patricia ; Santana, Jefferson S. ; Guadagnin, Rafael C. ; João Henrique G. Lago ; Pinto, Érika G. ; Tempone, André G. ; Stefani, Hélio A. ; Soares, Marisi G. ; Adalberto M. da Silva |
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Zeitschrift: | Química Nova, Jg. 35 (2012), Heft 4, S. 743-747 |
Veröffentlichung: | Sociedade Brasileira de Química, 2012 |
Medientyp: | academicJournal |
ISSN: | 1678-7064 (print) ; 0100-4042 (print) |
DOI: | 10.1590/S0100-40422012000400017 |
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