The hexokinase 'HKDC1' interaction with the mitochondria is essential for liver cancer progression
In: Cell Death and Disease, Jg. 13 (2022), Heft 7, S. 1-17
Online
academicJournal
Zugriff:
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellular energy by increasing glucose uptake. Also due to mitochondrial dysfunction there is enhanced ER stress and ER-mitochondrial interaction, leading to more calcium flux into the mitochondria. This multi-pronged effects of HKDC1 ablation leads to decreased cellular proliferation in LC.
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The hexokinase 'HKDC1' interaction with the mitochondria is essential for liver cancer progression
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Autor/in / Beteiligte Person: | Md. Wasim Khan ; Terry, Alexander R. ; Priyadarshini, Medha ; Ilievski, Vladimir ; Farooq, Zeenat ; Guzman, Grace ; Cordoba-Chacon, Jose ; Ben-Sahra, Issam ; Wicksteed, Barton ; Layden, Brian T. |
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Zeitschrift: | Cell Death and Disease, Jg. 13 (2022), Heft 7, S. 1-17 |
Veröffentlichung: | Nature Publishing Group, 2022 |
Medientyp: | academicJournal |
ISSN: | 2041-4889 (print) |
DOI: | 10.1038/s41419-022-04999-z |
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