Investigating the Anti-angiogenic Effects of Nanoemulsion Synthesized From Plant Anethum Graveolens L Essential Oil
In: Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, Jg. 24 (2021), Heft 1, S. 62-73
Online
academicJournal
Zugriff:
Background and Aim: Angiogenesis is the process of forming new blood vessels from the old ones; it plays an important role in physiological conditions, such as growth, wound healing, and reproduction. This process also plays a vital role in pathological phenomena and the occurrence of various diseases, especially tumor growth and metastasis. The present study evaluated the anti-angiogenic effects of nanoemulsion synthesized from Anethum graveolens essential oil using the CAM method. Methods & Materials: To investigate the anti-angiogenic effects on the second day of incubation, a window was opened on the eggs. Subsequently, on the eighth day, a gelatin sponge with nanoemulsion with different doses (12.5, 25, and 50 μg/mL) was inserted on the chorioallantoic membrane. On the 12th day of incubation, a research stereomicroscope was used to evaluate the rate of angiogenesis and imaging of the treated area. Vascular factors were examined by Image J software. Ethical Considerations: This study was approved by the Research Ethics Committee of Mashhad Branch, Islamic Azad University (Code: IR.IAU.MSHD.REC.1398.027). Results: The obtained results concerning the effect of nanoemulsion on the rate of angiogenesis in the CAM test indicated a decrease in the length and number of vessels of the chorioallantoic membrane in the treated samples, compared to the controls. Moreover, there was a reduction in the height and weight of treated fetuses, compared to the untreated fetuses (P
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Investigating the Anti-angiogenic Effects of Nanoemulsion Synthesized From Plant Anethum Graveolens L Essential Oil
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Autor/in / Beteiligte Person: | Haleh Sadat Tavakkol Afshari ; Masoud Homayouni Tabrizi ; Ardalan, Touran |
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Zeitschrift: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, Jg. 24 (2021), Heft 1, S. 62-73 |
Veröffentlichung: | Arak Medical University, 2021 |
Medientyp: | academicJournal |
ISSN: | 1735-5338 (print) ; 2008-644X (print) |
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