Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection
In: Journal of Functional Foods, Jg. 97 (2022-10-01), Heft 105225-
Online
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Zugriff:
A broad range of evidence has confirmed that natural products and essential oils might have the potential to suppress COVID-19 infection. Therefore, this study aimed to develop an oral/throat spray formulation for prophylactic use in the oral cavity or help treatment modalities. Based on a reference survey, several essential oils, a cold-pressed oil, and propolis were selected, and cytotoxicity and antiviral activity of each component and the developed spray formulation were examined against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using Vero E6 cells. Anti-inflammatory, antimicrobial, and analgesic activities as well as mutagenicity and anti-mutagenicity of the formulation were analysed. Forty-three phenolics were identified in both propolis extract and oral/throat spray. The spray with 1:640-fold dilution provided the highest efficacy and the cytopathic effect was delayed for 54 h at this dilution, and the antiviral activity rate was 85.3%. A combination of natural products with essential oils at the right concentrations can be used as a supplement for the prevention of SARS-CoV-2 infection.
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Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection
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Autor/in / Beteiligte Person: | Pelvan, Ebru ; Serhatlı, Müge ; Karaoğlu, Öznur ; Karadeniz, Bülent ; Ceyda Pembeci Kodolbaş ; Neşe Aslı Öncü ; Çakırca, Gamze ; Damarlı, Emel ; Başdoğan, Günay ; Gizem Mergen Duymaz ; İsmail Emir Akyıldız ; Düz, Gamze ; Acar, Sezer ; Özhan, Yağmur ; Sipahi, Hande ; Charehsaz, Mohammad ; Aydın, Ahmet ; Yesilada, Erdem ; Alasalvar, Cesarettin |
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Zeitschrift: | Journal of Functional Foods, Jg. 97 (2022-10-01), Heft 105225- |
Veröffentlichung: | Elsevier, 2022 |
Medientyp: | academicJournal |
ISSN: | 1756-4646 (print) |
DOI: | 10.1016/j.jff.2022.105225 |
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