Influence of the PPARy2 gene polymorphism on some metabolic indices in patients with essential arterial hypertension accompanied by ischemic heart disease and type 2 diabetes mellitus
In: Archives of the Balkan Medical Union, Jg. 53 (2018), Heft 1, S. 29-34
Online
academicJournal
Zugriff:
Introduction. Currently, numerous investigations have been conducted to study the role of various genes in the development of arterial hypertension, but still they do not contain data concerning patients with comorbid pathology. Objectives. To investigate the effect of Pro12Ala polymorphism of the PPAR2 gene on metabolism rates in patients with essential arterial hypertension accompanied by stable ischemic heart disease and type 2 diabetes mellitus. Methods. Indices of carbohydrate, lipid metabolism and oxidative-antioxidant protective activity in blood were studied in 50 patients with essential arterial hypertension accompanied by stable coronary heart disease (group I) and in 62 patients with essential hypertension accompanied by stable coronary heart disease and type 2 diabetes (group II). Results. In the Ist group of patients Pro/Pro genotype (82%) predominated, and in the II-nd group of patients Pro/Pro genotype was found in 85.5%, Pro/ Ala – in 14.5% of the patients. Significant impairments (p
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Influence of the PPARy2 gene polymorphism on some metabolic indices in patients with essential arterial hypertension accompanied by ischemic heart disease and type 2 diabetes mellitus
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Autor/in / Beteiligte Person: | Boiko, Vasyl V. ; Biletskyi, Semen V. ; Petrynych, Oksana A. ; Kazantseva, Tetiana V. ; Sheremet, Mykhailo I. |
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Zeitschrift: | Archives of the Balkan Medical Union, Jg. 53 (2018), Heft 1, S. 29-34 |
Veröffentlichung: | Balkan Medical Union, 2018 |
Medientyp: | academicJournal |
ISSN: | 1584-9244 (print) ; 2558-815X (print) |
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