The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study
In: Research Journal of Pharmacognosy, Jg. 5 (2018), Heft 1, S. 47-54
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Background and objectives: Sophora alopecuroides, one of the most important herbal medicines is widely grown in west of Iran, and has a long history for treatment of gastrointestinal diseases, leucorrhea, eczema, and psoriasis. The aim of this study was to investigate the ameliorative effect of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice. Methods: Thirty five male mice were divided into five groups; group I as the negative control, received olive oil intraperitoneally and distilled water orally. Group II as the positive control, received CCl4 mixed with olive oil in the ratio of 5:5, intraperitoneally and distilled water orally. Group III, IV and V received CCl4 and 200, 800 and 1600 µg/kg of S. alopecuroides essential oil through gavages for 45 consecutive days. Results: The results showed that low and intermediate doses of S. alopecuroides essential oil significantly decreased the raised levels of Alanine aminotrasferase and Aspartate aminotransaminase toward control levels (p
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The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study
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Autor/in / Beteiligte Person: | Goodarzi, N. ; Doorgard, E. ; Pournaghi, P. |
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Zeitschrift: | Research Journal of Pharmacognosy, Jg. 5 (2018), Heft 1, S. 47-54 |
Veröffentlichung: | Iranian Society of Pharmacognosy, 2018 |
Medientyp: | academicJournal |
ISSN: | 2345-5977 (print) |
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