Synapsin E-domain is essential for α-synuclein function
In: eLife, Jg. 12 (2024-05-01)
Online
academicJournal
Zugriff:
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.
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Synapsin E-domain is essential for α-synuclein function
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Autor/in / Beteiligte Person: | Stavsky, Alexandra ; Leonardo A Parra-Rivas ; Tal, Shani ; Riba, Jen ; Madhivanan, Kayalvizhi ; Roy, Subhojit ; Gitler, Daniel |
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Zeitschrift: | eLife, Jg. 12 (2024-05-01) |
Veröffentlichung: | eLife Sciences Publications Ltd, 2024 |
Medientyp: | academicJournal |
ISSN: | 2050-084X (print) |
DOI: | 10.7554/eLife.89687 |
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