Anti-Cancer Effects of Nanoliposomes Containing Rosemary and Zataria multiflora Boiss Essential Oils on HepG2 Cell Line under in Vitro Conditions
In: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Jg. 24 (2022), Heft 1, S. 141-150
Online
academicJournal
Zugriff:
Background and Objective: In recent years, with increasing interest in the use of natural substances such as essential oils, extensive studies have been conducted to use them more efficiently in the form of nanoliposomes. The present study was conducted to investigate the anti-cancer effects of nanoliposomes containing Rosemary and Zataria multiflora Boiss essential oils on HepG2 cell line under in vitro conditions. Methods: In this basic-applied research, nanoliposomes containing Rosemary and Zataria multiflora Boiss essential oils were used. The mortality rate of HepG2 cell line was calculated using MTT method and IC50 was obtained. The study groups calculated according to IC50 were: control group, the group receiving 79.72 μg/ml Zataria multiflora Boiss nanoliposome for 48 hours and the group receiving 53.50 μg/ml Rosemary nanoliposome for 72 hours. The rate of apoptosis and necrosis of cancer cells and the type of cancer cell cycle were determined by flow cytometry. Findings: The results showed that nanoliposomes containing Rosemary essential oil after 72 hours (53.50 μg/ml) and Zataria multiflora Boiss after 48 hours (79.72 μg/ml) showed the highest capability to inhibit the growth of HepG2 cell line (p
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Anti-Cancer Effects of Nanoliposomes Containing Rosemary and Zataria multiflora Boiss Essential Oils on HepG2 Cell Line under in Vitro Conditions
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Autor/in / Beteiligte Person: | Ghafarkhani, S ; Aarabi, MH ; Safari, M ; M Shafee Ardestani ; Kheiripour, N |
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Zeitschrift: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Jg. 24 (2022), Heft 1, S. 141-150 |
Veröffentlichung: | Babol University of Medical Sciences, 2022 |
Medientyp: | academicJournal |
ISSN: | 1561-4107 (print) ; 2251-7170 (print) |
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