Compositional Variation and Bioactivity of the Leaf Essential Oil of Montanoa guatemalensis from Monteverde, Costa Rica: A Preliminary Investigation
In: Medicines, Jg. 2 (2015), Heft 4, S. 331-339
Online
academicJournal
Zugriff:
Background: Montanoa guatemalensis is a small to medium-sized tree in the Asteraceae that grows in Central America from Mexico south through Costa Rica. There have been no previous investigations on the essential oil of this tree. Methods: The leaf essential oils of M. guatemalensis were obtained from different individual trees growing in Monteverde, Costa Rica, in two different years, and were analyzed by gas chromatography—mass spectrometry. Results: The leaf oils from 2008 were rich in sesquiterpenoids, dominated by α-selinene, β-selinene, and cyclocolorenone, with lesser amounts of the monoterpenes α-pinene and limonene. In contrast, the samples from 2009 showed no α- or β-selinene, but large concentrations of trans-muurola-4(14),5-diene, β-cadinene, and cyclocolorenone, along with greater concentrations of α-pinene and limonene. The leaf oils were screened for cytotoxic and antimicrobial activities and did show selective cytotoxic activity on MDA-MB-231 breast tumor cells. Conclusion: M. guatemalensis leaf oil, rich in cyclocolorenone, α-selinene, and β-selinene, showed selective in vitro cytotoxic activity to MDA-MB-231 cells. The plant may be a good source of cyclocolorenone.
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Compositional Variation and Bioactivity of the Leaf Essential Oil of Montanoa guatemalensis from Monteverde, Costa Rica: A Preliminary Investigation
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Autor/in / Beteiligte Person: | Flatt, Victoria D. ; Campos, Carlos R. ; Kraemer, Maria P. ; Bailey, Brittany A. ; Satyal, Prabodh ; Setzer, William N. |
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Zeitschrift: | Medicines, Jg. 2 (2015), Heft 4, S. 331-339 |
Veröffentlichung: | MDPI AG, 2015 |
Medientyp: | academicJournal |
ISSN: | 2305-6320 (print) |
DOI: | 10.3390/medicines2040331 |
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