Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation
In: FEBS Open Bio, Jg. 4 (2014), Heft C, S. 468-472
Online
academicJournal
Zugriff:
According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.
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Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation
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Autor/in / Beteiligte Person: | Karlyshev, A.V. ; Thacker, G. ; Jones, M.A. ; Clements, M.O. ; Wren, B.W. |
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Zeitschrift: | FEBS Open Bio, Jg. 4 (2014), Heft C, S. 468-472 |
Veröffentlichung: | Wiley, 2014 |
Medientyp: | academicJournal |
ISSN: | 2211-5463 (print) |
DOI: | 10.1016/j.fob.2014.04.012 |
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