Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry
In: Scientific Reports, Jg. 14 (2024), Heft 1, S. 1-16
Online
academicJournal
Zugriff:
Abstract Patients with drug-resistant essential tremor (ET) may undergo Gamma Knife stereotactic radiosurgical thalamotomy (SRS-T), where the ventro-intermediate nucleus of the thalamus (Vim) is lesioned by focused beams of gamma radiations to induce clinical improvement. Here, we studied SRS-T impacts on left Vim dynamic functional connectivity (dFC, n = 23 ET patients scanned before and 1 year after intervention), and on surface-based morphometric brain features (n = 34 patients, including those from dFC analysis). In matched healthy controls (HCs), three dFC states were extracted from resting-state functional MRI data. In ET patients, state 1 spatial stability increased upon SRS-T (F 1,22 = 19.13, p = 0.004). More frequent expression of state 3 over state 1 before SRS-T correlated with greater clinical recovery in a way that depended on the MR signature volume (t 6 = 4.6, p = 0.004). Lower pre-intervention spatial variability in state 3 expression also did (t 6 = − 4.24, p = 0.005) and interacted with the presence of familial ET so that these patients improved less (t 6 = 4.14, p = 0.006). ET morphometric profiles showed significantly lower similarity to HCs in 13 regions upon SRS-T (z ≤ − 3.66, p ≤ 0.022), and a joint analysis revealed that before thalamotomy, morphometric similarity and states 2/3 mean spatial similarity to HCs were anticorrelated, a relationship that disappeared upon SRS-T (z ≥ 4.39, p
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Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry
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Autor/in / Beteiligte Person: | Bolton, Thomas A. W. ; Dimitri Van De Ville ; Régis, Jean ; Witjas, Tatiana ; Girard, Nadine ; Levivier, Marc ; Tuleasca, Constantin |
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Zeitschrift: | Scientific Reports, Jg. 14 (2024), Heft 1, S. 1-16 |
Veröffentlichung: | Nature Portfolio, 2024 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (print) |
DOI: | 10.1038/s41598-024-52410-y |
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