BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling
In: International Journal of Molecular Sciences, Jg. 25 (2024-05-01), Heft 9, S. 4962-4962
Online
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Zugriff:
B cell receptor-associated protein 31 (BAP31) is a transmembrane protein that is widely expressed and primarily located in the endoplasmic reticulum (ER). B cells play a crucial role in the immune system, and BAP31 significantly contributes to the functions of various immune cells. However, the specific role of BAP31 in B lymphocytes development remains unknown. In this study, we utilized a mouse model with BAP31 deleted from B cells to investigate its effects. Our findings reveal a block in early B cell development in the bone marrow and a significant decrease in the number of B cells in peripheral lymphoid organs taken from BAP31 B cell conditional knockout (BAP31-BCKO) mice. B cell receptor (BCR) signaling is crucial for the normal development and differentiation of B lymphocytes. BAP31, an endoplasmic reticulum membrane protein, directly regulates the BCR signaling pathway and was shown to be significantly positively correlated with B cell activation and proliferation. These findings establish BAP31 as a crucial regulator of early B cell development.
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BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling
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Autor/in / Beteiligte Person: | Zhao, Bo ; An, Fei ; Hao, Zhenzhen ; Zhang, Wanting ; Wang, Bing |
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Zeitschrift: | International Journal of Molecular Sciences, Jg. 25 (2024-05-01), Heft 9, S. 4962-4962 |
Veröffentlichung: | MDPI AG, 2024 |
Medientyp: | academicJournal |
ISSN: | 1422-0067 (print) ; 1661-6596 (print) |
DOI: | 10.3390/ijms25094962 |
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