Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae)
In: Natural Product Communications, 2014
Online
academicJournal
Zugriff:
The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galicica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and beta-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 mu g/mL against S. epidermidis to 50 mu g/mL against P. aerugmosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRCS cells. The essential oil from Korab demonstrated significantly better results than the oil from Galicica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 mu g/mL, while the oil from Galicica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 mu g/mL).
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Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae)
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Autor/in / Beteiligte Person: | Kundaković, Tatjana ; Stanojković, Tatjana ; Kolundžija, Branka ; Marković, Stevan ; Šukilović, Branka ; Milenković, Marina ; Lakušić, Branislava |
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Zeitschrift: | Natural Product Communications, 2014 |
Veröffentlichung: | Sage Publications Inc, Thousand Oaks, 2014 |
Medientyp: | academicJournal |
ISBN: | 978-0-00-335083-8 (print) ; 0-00-335083-5 (print) |
ISSN: | 1934-578X (print) |
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