CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation ; CD147/basigin のTh 細胞分化と乾癬病態形成に関する包括的研究

鹿児島大学 ; 博士(医学) ; Doctor of Philosophy in Medical Science ; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 ; Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with monocarboxylate transporters (MCTs)-1 and -4 in cancer cells and T cells. We examined whether CD147/basigin is involved in the pathogenesis of psoriasis in humans and psoriasis-model mice. The serum level of CD147 was increased in patients with psoriasis, and the expression of CD147 and MCT-1 was elevated in their dermal CD4+ RORγt+ T cells. In vitro, the potential of naïve CD4+ T cells to differentiate into Th17 cells was abrogated in CD147−/− T cells. Imiquimod (IMQ)-induced psoriatic dermatitis was significantly milder in CD147−/− mice and bone marrow chimeric mice lacking CD147 in the hematopoietic cells of myeloid lineage. These findings demonstrate that CD147 is essential for the development of psoriasis via the induction of Th17 cell differentiation. Aoi Okubo, Youhei Uchida, Yuko Higashi, Takuya Sato, Youichi Ogawa, Akihiro Ryuge, Kenji Kadomatsu and Takuro Kanekura CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation International Journal of Molecular Sciences 2022, 23, 177 https://doi.org/10.3390/ijms23010177 ; doctoral thesis