ANTITUMOR EFFECTS OF TANACETUM BALSAMITA ESSENTIAL OILS BY DOWNREGULATION NRF-2 AND MMP-9 IN BREAST CANCER
Faculty of Agronomy in Čačak, University of Kragujevac, 2024
Online
Konferenz
Zugriff:
The aim of this study was to investigate antitumor capacity of different Tanacetum balsamita essential oils by measuring apoptosis rate, MMP-9 concetration and Nrf-2 expression level in human MBA-MB-468 and MDA-MB-231 cells. The tested EOs expressed proapoptotic effects, significantly inhibited the MMP-9 concentration and down-regulated the expression level of Nrf-2. The obtained data suggest that the tested EOs exert considerable antitumor activity elevating apoptosis level and inhibiting the motility of tested cancer cells. The reduced levels of Nrf-2 expression suggest decreased defense potential for oxidative disturbances, which could be the major antitumor mechanism detected in the study. ; Published
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ANTITUMOR EFFECTS OF TANACETUM BALSAMITA ESSENTIAL OILS BY DOWNREGULATION NRF-2 AND MMP-9 IN BREAST CANCER
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Autor/in / Beteiligte Person: | Obradović, Ana ; Vukić, Milena ; Paunović, Milica ; Ognjanović, Branka ; Vukovic, Nenad ; Kačániová, Miroslava ; Matić, Miloš |
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Veröffentlichung: | Faculty of Agronomy in Čačak, University of Kragujevac, 2024 |
Medientyp: | Konferenz |
ISBN: | 978-86-87611-91-7 (print) ; 86-87611-91-9 (print) |
DOI: | 10.46793/SBT29.71AO |
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