Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities
In: Frontiers in Chemistry ; volume 12 ; ISSN 2296-2646, 2024
Online
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Zugriff:
Introduction: This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial ( Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa ) and fungal ( Candida glabrata, Rhodotorula glutinis, Aspergillus niger, Penicillium digitatum ) strains. Antidiabetic and anti-gout potential were investigated through α-amylase, α-glucosidase, and xanthine oxidase inhibition assays. Antityrosinase activity was determined using a modified dopachrome method. Cytotoxicity was assessed by MTT assay against breast (MCF-7, MDA-MB-468), liver (HepG2), colon (HCT-15) cancer cells, and normal cells (PBMCs). Results and discussion: LPEO exhibits potent antiradical activity (IC50 = 148.33 ± 2.48 μg/mL) and significant antioxidant capacity (TAC = 171.56 ± 2.34 μg AA/mg of EO). It demonstrates notable antibacterial activity against four strains ( Staphylococcus aureus, Micrococcus luteus, Escherichia coli, and Pseudomonas aeruginosa ) with inhibition zones ranging from 18.70 ± 0.30 mm to 29.20 ± 0.30 mm, along with relatively low MIC and MBC values. LPEO displays significant antifungal activity against four strains ( Candida glabrata, Rhodotorula glutinis, Aspergillus niger, and Penicillium digitatum ) with a fungicidal effect at 1 mg/mL, surpassing the positive control (cycloheximide), and MIC and MFC values indicating a fungicidal effect. It exhibits substantial inhibition of xanthine oxidase enzyme (IC50 = 26.48 ± 0.90 μg/mL), comparable to allopurinol, and marked inhibitory effects on α-amylase (IC50 = 31.56 ± 0.46 μg/mL) and α-glucosidase (IC50 = 58.47 ± 2.35 μg/mL) enzymes.The enzyme tyrosinase is ...
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Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities
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Autor/in / Beteiligte Person: | Haddou, Mounir ; Elbouzidi, Amine ; Taibi, Mohamed ; Baraich, Abdellah ; Loukili, El Hassania ; Bellaouchi, Reda ; Saalaoui, Ennouaamane ; Asehraou, Abdeslam ; Salamatullah, Ahmad Mohammad ; Bourhia, Mohammed ; Nafidi, Hiba-Allah ; Addi, Mohamed ; Guerrouj, Bouchra El ; Chaabane, Khalid |
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Zeitschrift: | Frontiers in Chemistry ; volume 12 ; ISSN 2296-2646, 2024 |
Veröffentlichung: | Frontiers Media SA, 2024 |
Medientyp: | academicJournal |
DOI: | 10.3389/fchem.2024.1383731 |
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