Autophagy is essential for effector CD8 + T cell survival and memory formation
In: Nature Immunology, 2014
Online
academicJournal
Zugriff:
The importance of autophagy in the generation of memory CD8 + T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8 + T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8 + T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy.
Titel: |
Autophagy is essential for effector CD8 + T cell survival and memory formation
|
---|---|
Autor/in / Beteiligte Person: | Xu, X. ; Araki, K. ; Li, S. ; Han, J. ; Ye, L. ; Tan, W. ; Konieczny, B. ; Bruinsma, M. ; Martinez, J. ; Pearce, E. ; Green, D. ; Jones, D. ; Virgin, H. ; Ahmed, R. |
Link: | |
Zeitschrift: | Nature Immunology, 2014 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
Schlagwort: |
|
Sonstiges: |
|