Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies
2023
Online
academicJournal
Zugriff:
The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo -intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o -cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 µg/mL) and S. mutans (MIC 250 µg/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 µg/mL. The molecular docking study shows neo -intermedeol, eudesma-4,11-dien-3-one, α-selinene, and β-selinene as the good candidate to target Erg11 with a binding energy of −7.3 kcal/mol. These findings demonstrated that the essential oil may have potential in dental application for caries prevention.
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Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies
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Autor/in / Beteiligte Person: | Nur Nabilah Mohd Zaini ; Wan Mohd Nuzul Hakimi Wan Salleh ; Mohd Hafiz Arzmi ; Abubakar Siddiq Salihu ; Nurunajah Ab Ghani |
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Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.24903300.v1 |
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