Anti-inflammatory and antioxidant activities of Citrus aurantifolia (Christm.) Swingle essential oil in dystrophic muscle cells: implication of the PGC-1α pathway
2024
Online
academicJournal
Zugriff:
The commercial essential oil obtained from the steam distillation of cold-pressed oil from Citrus aurantifolia (Christm.) Swingle fruits (OCA), after chemical characterization by gas chromatography-mass spectrometry (GC-MS), was investigated for antioxidant and anti-inflammatory activities and related signaling pathways in dystrophic muscle cells. The chemical composition of OCA showed 24 compounds with a predominance of monoterpenes, such as limonene (42.6%), cymene (11.8%), α-terpineol (11.8%), terpinolene (5.3%) and γ-terpinene (4.6%). DPHH and ORAC assays showed a significant antioxidant activity of OCA. Because the OCA is rich in limonene, it exhibited marked anti-inflammatory (as indicated by the reduction of TNF- α and NF-κB levels) and antioxidant effects (as indicated by the reduction of 4-HNE-protein adducts, SOD-2, GSR and H 2 O 2 levels) on dystrophic muscle cells. These effects appear to be mediated through the activation of PGC-1α pathway. Therefore, OCA can be considered a promising bioactive for therapeutic applications in dystrophinopathies.
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Anti-inflammatory and antioxidant activities of Citrus aurantifolia (Christm.) Swingle essential oil in dystrophic muscle cells: implication of the PGC-1α pathway
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Autor/in / Beteiligte Person: | Fernanda dos Santos Rapucci Moraes ; Luis Henrique Rapucci Moraes ; Aline Barbosa Macedo ; Amanda Harduim Valduga ; Daniela Sayuri Mizobuti ; Guilherme Luiz da Rocha ; Heloina Nathalliê Mariano da Silva ; Marcos José Salvador ; Minatel, Elaine |
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Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.24947341.v1 |
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