The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 203 (2018-12-04), Heft 1
Online
unknown
Zugriff:
Access to nutrients is critical for an effective T cell immune response to infection. Although transporters for sugars and amino acids have previously been described in the context of the CD8(+) T cell immune response, the active transport of exogenous fatty acids has remained enigmatic. Here we discovered the sodium-dependent lysophosphatidylcholine transporter, Major Facilitator Super Family Domain Containing 2a (MFSD2A), is upregulated on activated CD8(+) T cells and is required for memory T cell maintenance. MFSD2A deficiency in mice resulted in decreased import of lysophosphatidylcholine (LPC) esterified to long chain fatty acids (LCFAs) into activated CD8(+) T cells, and MFSD2A deficient cells are at a competitive disadvantage resulting in reduced memory T cell formation and maintenance and reduced response to secondary infection. Mechanistically, import of LPCs was required to maintain T cell homeostatic turnover, that when lost resulted in a decreased memory T cell pool and thus a reduced secondary response to repeat infection.
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The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8
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Autor/in / Beteiligte Person: | Ann R, Piccirillo ; Eric J, Hyzny ; Lisa Y, Beppu ; Ashley V, Menk ; Callen T, Wallace ; William F, Hawse ; Heather M, Buechel ; Bernice H, Wong ; Juat Chin, Foo ; Amaury, Cazenave-Gassiot ; Markus R, Wenk ; Greg M, Delgoffe ; Simon C, Watkins ; David L, Silver ; Louise M, D'Cruz |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 203 (2018-12-04), Heft 1 |
Veröffentlichung: | 2018 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) |
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