IL-21 Receptor Signaling Is Essential for Optimal CD4
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 199 (2016-07-15), Heft 8
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Zugriff:
In the current study we determined the role of IL-21 receptor signaling in Mycobacterium tuberculosis (Mtb) infection, using IL-21 receptor knockout (IL-21R KO) mice. Fifty percent of Mtb H37Rv infected IL-21R KO mice died in six months compared to no deaths in infected wild type (WT) mice. Mtb infected IL-21R KO mice had enhanced bacterial burden and reduced infiltration of antigen specific T-cells in lungs compared to Mtb infected WT mice. Antigen specific T-cells from the lungs of Mtb infected IL-21R KO mice had increased expression of T-cell inhibitory receptors, reduced expression of chemokine receptors, proliferated less and produced less IFN- γ, compared to antigen specific T cells from the lungs of Mtb infected WT mice. T cells from Mtb infected IL-21R KO mice were unable to induce optimal macrophage responses to Mtb. This may be due to a decrease in the antigen specific T cell population. We also found that IL-21R signaling is associated with reduced expression of a transcriptional factor Eomesodermin (Eomes) and enhanced functional capacity of antigen specific T-cells of Mtb infected mice. The sum of our findings suggests that IL-21 receptor signaling is essential for the optimal control of Mtb infection.
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IL-21 Receptor Signaling Is Essential for Optimal CD4
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Autor/in / Beteiligte Person: | Satyanarayana Swamy, Cheekatla ; Deepak, Tripathi ; Sambasivan, Venkatasubramanian ; Padmaja, Paidipally ; Elwyn, Welch ; Amy R, Tvinnereim ; Roza, Nurieva ; Ramakrishna, Vankayalapati |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 199 (2016-07-15), Heft 8 |
Veröffentlichung: | 2016 |
Medientyp: | unknown |
ISSN: | 1550-6606 (print) |
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