Effect of the Essential Oil from the Flowers of Magnolia sieboldii on the Lipopolysaccharide-Induced Production of Nitric Oxide and Prostaglandin E2 by Rat Peritoneal Macrophages
In: Planta Medica, Jg. 68 (2002-05-01), S. 459-462
Online
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Zugriff:
The essential oil from the flowers of Magnolia sieboldii was tested for its effects on lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) by rat peritoneal macrophages. It was shown to induce the production of NO and PGE 2 in a concentration-dependent manner (3 - 30 microg/ml). Gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) led to the identification of sixty compounds, of which beta-elemene (18.0 %), alpha-terpinene (14.83 %) and beta-myrcene (12.72 %) were the major constituents. Among these three compounds, alpha-terpinene was found to be the most effective one with inhibitory activity on NO and PGE(2) production by LPS-stimulated rat peritoneal macrophages.
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Effect of the Essential Oil from the Flowers of Magnolia sieboldii on the Lipopolysaccharide-Induced Production of Nitric Oxide and Prostaglandin E2 by Rat Peritoneal Macrophages
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Autor/in / Beteiligte Person: | Soon Sung Lim ; Hyun Seung Ban ; Sang Hoon Jung ; Yoo Jeung Kim ; Kuk Hyun Shin ; Ohuchi, Kazuo ; Yong Pil Kim |
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Zeitschrift: | Planta Medica, Jg. 68 (2002-05-01), S. 459-462 |
Veröffentlichung: | Georg Thieme Verlag KG, 2002 |
Medientyp: | unknown |
ISSN: | 1439-0221 (print) ; 0032-0943 (print) |
DOI: | 10.1055/s-2002-32085 |
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