Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis
In: Journal of immunology (Baltimore, Md. : 1950), Jg. 180 (2008-01-08), Heft 2
Online
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Zugriff:
Experimental autoimmune encephalomyelitis (EAE) is one of the best-documented animal models of autoimmune disease. We examined the role of CD8+CD122+ regulatory T cells, which we previously identified as naturally occurring regulatory T cells that effectively regulate CD8+ T cells, in EAE. Depletion of CD8+CD122+ regulatory T cells by in vivo administration of anti-CD122 mAb resulted in persistent EAE symptoms. Transfer of CD8+CD122+ regulatory T cells into EAE mice at the peak EAE score clearly improved symptoms, indicating an important role of CD8+CD122+ regulatory T cells in the recovery phase of EAE. This was further confirmed by an increase and a decrease in the number of infiltrating T cells in the CNS and T cell cytokine production in mice that were depleted of or complemented with CD8+CD122+ cells. Furthermore, transfer of preactivated CD8+CD122+ regulatory T cells resulted in diminished EAE symptoms, especially in the recovery phase of EAE. These results elucidate the essential role of CD8+CD122+ regulatory T cells in the recovery phase of EAE and suggest the preventive effect of preactivated CD8+CD122+ regulatory T cells for EAE.
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Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis
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Autor/in / Beteiligte Person: | Rifa'i, Muhaimin ; Suzuki, Haruhiko ; Ishida, Yoshiyuki ; Lee, Youngho ; Shi, Zhe ; Isobe, Ken-ichi |
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Zeitschrift: | Journal of immunology (Baltimore, Md. : 1950), Jg. 180 (2008-01-08), Heft 2 |
Veröffentlichung: | 2008 |
Medientyp: | unknown |
ISSN: | 0022-1767 (print) |
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