Essential trace elemental levels (zinc, iron and copper) in the biological samples of smoker referent and pulmonary tuberculosis patients
In: Toxicology Reports, Jg. 6 (2019-11-01), S. 1230-1239
Online
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Graphical abstract
Highlights • Smoking is linked with tuberculosis recurrence. • Pakistan has not only high TB number of TB cases (fifth) but also high level of multidrug-resistant TB (fourth) in the world. • Cu/Zn ratio was also considerably greater in all biological samples of TB patients as compared to the control group. • The analysis the levels of the elements, {Fe, Cu, Zn and Cu/Zn ratio} may help the studies on the development of TB disease.
Tuberculosis is one of the major causes of illnesses and deaths throughout world particularly in Asia. Smoking is linked with tuberculosis recurrence and its mortality and may influence bacteriological conversion, clinical symptoms and treatment outcome. The aim of current study was to estimate association among essential trace elements {zinc (Zn), iron (Fe) and copper (Cu)} in human biological samples particularly blood, serum, scalp hair, saliva, sputum, and nasal fluid of smoking and nonsmoking pulmonary tuberculosis patients (n = 165, age ranged 16–35 years) residents of Hyderabad, Pakistan. The biological samples of age matched healthy controls were chosen as referents of both genders (n = 171) for the comparison purpose. The human biological samples were wet digested in microwave oven by 65 % HNO3 and 30 % H2O2 with (2:1) ratio. The concentrations of elements in acid digested samples were determined by atomic absorption spectrometry. The average zinc and iron concentration was lower, while level of copper was higher in the biological samples of pulmonary Tuberculosis patients as compared to referent subjects (p
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Essential trace elemental levels (zinc, iron and copper) in the biological samples of smoker referent and pulmonary tuberculosis patients
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Autor/in / Beteiligte Person: | Jameel Ahmed Baig ; Tasneem Gul Kazi ; Hassan Imran Afridi ; Farah Naz Talpur ; Nizamani, Palwasha |
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Zeitschrift: | Toxicology Reports, Jg. 6 (2019-11-01), S. 1230-1239 |
Veröffentlichung: | Elsevier, 2019 |
Medientyp: | unknown |
ISSN: | 2214-7500 (print) |
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