Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension
In: Journal of Human Hypertension, Jg. 11 (1997-08-01), S. 527-532
Online
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Zugriff:
In response to a high sodium (Na+) intake, salt-sensitive patients with hypertension retain more Na+ and manifest a greater rise in arterial pressure than salt-resistant patients. Because there is limited information regarding the role of nitric oxide (NO) in salt-sensitivity we examined the effects of L-arginine (500 mg/kg, i.v. for 30 min) on mean arterial pressure and renal haemodynamics in 21 hypertensive and five normotensive African-Americans. At the end of L-arginine infusion mean arterial pressure fell more in salt-sensitive (-11.5 +/- 2.5) than in salt-resistant (-3.7 +/- 1.5 mm Hg) and control subjects (-3.2 +/- 3.8 mm Hg). At the end of L-arginine infusion effective renal plasma flow (ERPF) increased more (P < 0.05) in controls (+108 +/- 13.9 ml/min/1.73 m2) than in salt-resistant (+55 +/- 16.0 ml/min/1.73 m2) and salt-sensitive patients (+22 +/- 21.5 ml/min/1.73 m2). This study has shown that salt-sensitive African-Americans manifest different systemic and renal haemodynamic responses to L-arginine than salt-resistant patients and controls. The fall in mean blood pressure following L-arginine was greater in salt-sensitive than in salt-resistant patients and controls, whereas the increase in ERPF was reduced in salt-sensitive compared to salt-resistant and normal subjects. The data are in keeping with the notion that a defect in NO production may participate to the genesis of blood pressure sensitivity to salt.
Titel: |
Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension
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Autor/in / Beteiligte Person: | Amar, M ; Wurgaft, A ; V M Campese ; Anjali, C ; Medhat, T. |
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Zeitschrift: | Journal of Human Hypertension, Jg. 11 (1997-08-01), S. 527-532 |
Veröffentlichung: | Springer Science and Business Media LLC, 1997 |
Medientyp: | unknown |
ISSN: | 1476-5527 (print) ; 0950-9240 (print) |
DOI: | 10.1038/sj.jhh.1000485 |
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