Circulating Digitalis-Like Compounds in Essential Hypertension
In: Clinical and Experimental Hypertension. Part A: Theory and Practice, Jg. 6 (1984), S. 441-453
Online
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Zugriff:
Inhibitors of the Na+ pump have been proposed as participating in sodium excretion, extracellular fluid regulation, and in the rise of blood pressure. The presence of digitalis-like compounds in human plasma has been investigated by comparing the effects of plasma extracts to those of ouabain in 4 tests. - competition with ouabain for binding to the Na+ pump, - inhibition of Na+ and K+ dependent hydrolysis - inhibition of serotonin uptake by human platelets - central hypertensive effect Plasma fractions exhibited digitalis-like properties in the 4 tests. The effects of plasma extracts of 42 normotensive subjects (21 with family history of hypertension) and 38 patients with essential hypertension (15 with antihypertensive treatment) and 9 patients with chronic renal failure were compared. Plasma from Forty per cent of untreated hypertensive patients and normotensives with hypertensive heredity had a high inhibition level. Inhibition was enhanced in beta-blocker treated patients and decreased in those on diuretics. No digitalis-like activity was observed in uremic plasma. These observations strongly suggest the presence of digitalis-like compound(s) in human plasma and point to its possible association with hypertension.
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Circulating Digitalis-Like Compounds in Essential Hypertension
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Autor/in / Beteiligte Person: | Devynck, M. A. ; Pernollet, M. G. ; Cloix, J. F. ; H. De The ; Kamal, L. ; Elghozi, J. L. ; Rosenfeld, J. ; Meyer, P. |
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Zeitschrift: | Clinical and Experimental Hypertension. Part A: Theory and Practice, Jg. 6 (1984), S. 441-453 |
Veröffentlichung: | Informa UK Limited, 1984 |
Medientyp: | unknown |
ISSN: | 0730-0077 (print) |
DOI: | 10.3109/10641968409062576 |
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