Chemical composition and antiproliferative activity of Croton campestris A.St.-Hil. essential oil
In: Natural Product Research, Jg. 33 (2017-11-09), S. 580-583
Online
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Zugriff:
Herein, the antiproliferative potential of the essential oil obtained from fresh leaves of Croton campestris against human tumour cell lines was investigated for the first time. Furthermore, the essential oil obtained by hydrodistillation had the composition determined by gas chromatography–mass spectrometry (GC/MS). Ten major components were identified that comprised 91.59% of the total content, with 23.8% consisting of (Z)-caryophyllene and 16.08% consisting of γ-elemene as main components. The cytotoxic activity was observed mainly for breast (MCF-7) and colon (HT-29) human tumour cell lines, with GI50 (50% growth inhibition) concentration of 8.61 and 9.94 μg/mL, respectively. The results of this study showed that the essential oil obtained from Croton campestris A.St.-Hil. represents a potential source for the search of new antitumour agents.
| Titel: |
Chemical composition and antiproliferative activity of Croton campestris A.St.-Hil. essential oil
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| Autor/in / Beteiligte Person: | Ana Lúcia Tasca Gois Ruiz ; Ícaro Augusto Maccari Zelioli ; Mary Ann Foglio ; Ilza Maria de Oliveira Sousa ; Carvalho, João ; Monteiro, Paula A. ; Débora Barbosa Vendramini-Costa |
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| Zeitschrift: | Natural Product Research, Jg. 33 (2017-11-09), S. 580-583 |
| Veröffentlichung: | Informa UK Limited, 2017 |
| Medientyp: | unknown |
| ISSN: | 1478-6427 (print) ; 1478-6419 (print) |
| DOI: | 10.1080/14786419.2017.1399377 |
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