Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
In: Case Reports in Hematology, Jg. 2016 (2016)
Online
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Zugriff:
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexistingJAK2V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed hematopoietic progenitor cells, respectively. Mutations ofCALRin essential thrombocythemia appear to be associated with a distinct phenotype and a lower risk of thrombosis yet their impact on disease progression is less well defined. The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising inCALRmutated essential thrombocythemia is presented. Intensive treatment for the leukemia allowed for expansion of the originalCALRmutated clone. WhetherCALRmutations in myeloproliferative neoplasms predispose to the acquisition of additional malignancies, particularly lymphoproliferative disorders, is not yet known.
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Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
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Autor/in / Beteiligte Person: | Langabeer, Stephen E. ; Bacon, Christopher L. ; Haslam, Karl ; Ryan, Ciara ; Kelly, Johanna ; O'Brien, David ; Andrews, Claire ; Hayden, Patrick ; Flavin, Richard |
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Zeitschrift: | Case Reports in Hematology, Jg. 2016 (2016) |
Veröffentlichung: | Hindawi Limited, 2016 |
Medientyp: | unknown |
ISSN: | 2090-6579 (print) ; 2090-6560 (print) |
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