The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats
In: Molecules, Jg. 25 (2020-07-20), Heft 3284, p 3284
Online
unknown
Zugriff:
C. citratus essential oil and carvacrol have shown an antitumor effect on breast tumor cell lines
the main objective of this research was to evaluate the antitumor effect of the essential oil of Cymbopogon citratus (EOCc) and carvacrol on 7,12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer in female rats. Cancer was induced by a single administration of DMBA at dose of 80 mg/kg body weight (BW). A total of 54 female Holtzman rats were randomly assigned into 9 groups (n = 6). Group I: PS (Physiological saline)
Group II: DMBA
Groups III, IV, and V: DMBA + EOCc at doses of 50, 100 and 200 mg/kg/day BW, respectively
Groups VI, VII, and VIII: DMBA + carvacrol at doses of 50, 100 and 200 mg/kg/day BW, respectively
and group IX: DMBA + EOCc + carvacrol at doses of 100 mg/kg/day BW. The treatment lasted 14 weeks. As results, EOCc showed a reduction in tumors as well as necrosis and mitosis. Animals treated with carvacrol did not show necrosis, mitosis, or infiltration. Carvacrol at dose of 100 mg/kg/day BW revealed a significant decrease in the cumulative tumor volume down to 0.11 ±
0.05 cm3 compared to 0.38 ±
0.04 cm3 of the DMBA group (p <
0.01). It is concluded that EOCc and carvacrol had an antitumor effect on DMBA-induced breast cancer in female rats.
| Titel: |
The Essential Oil of Cymbopogon citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats
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| Autor/in / Beteiligte Person: | Calva, James ; Rojas-Armas, Agustín ; Juan Pedro Rojas-Armas ; Jorge Luis Arroyo-Acevedo ; Palomino-Pacheco, Miriam ; Hilario-Vargas, Julio ; Castro-Luna, Américo ; José Manuel Ortiz-Sánchez ; Herrera-Calderon, Oscar |
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| Zeitschrift: | Molecules, Jg. 25 (2020-07-20), Heft 3284, p 3284 |
| Veröffentlichung: | Multidisciplinary Digital Publishing Institute, 2020 |
| Medientyp: | unknown |
| ISSN: | 1420-3049 (print) |
| DOI: | 10.3390/molecules25143284 |
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