Serum Interleukin-15 Concentration in Patients With Essential Hypertension
In: American Journal of Hypertension, Jg. 18 (2005-08-01), S. 1019-1025
Online
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Zugriff:
Interleukin (IL)-15 is one of the cytokines produced by neutrophils and monocytes/macrophages, and its expression is found immunohistochemically in inflammatory cells adjacent to vulnerable atherosclerotic plaques. However, the influence of systemic IL-15 on cardiovascular disease is still unclear. Therefore, we designed clinical investigations to clarify the relationship between cardiovascular complications and serum IL-15 levels.Three hundred ninety-nine patients with essential hypertension were analyzed. We divided the study subjects into the following three groups according to the modified World Health Organization-International Society of Hypertension classification of 1999: patients with no organ damage (n = 213), patients with mild organ damage (n = 128), and patients with severe organ damage (n = 58). We measured serum IL-15, highly sensitive C reactive protein, IL-6, soluble intercellular adhesion molecule, and soluble vascular cell adhesion molecule levels. Serum IL-15 concentration in patients with severe organ damage was significantly higher than that in those with no organ damage (P.01) and those with mild organ damage (P.01). Serum IL-15 concentration in patients with coronary artery disease or peripheral artery disease was significantly higher than that in those without coronary artery disease or peripheral artery disease. Moreover, serum IL-15 concentration in patients with lacunar infarction was significantly higher than that in those without lacunar infarction (P.005). By multiple linear logistic regression analysis, serum IL-15 concentration was independently correlated with cardiovascular disease.These data suggest that a systemic inflammatory response involving IL-15 might be involved in the occurrence of cardiovascular disease in patients with essential hypertension.
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Serum Interleukin-15 Concentration in Patients With Essential Hypertension
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Autor/in / Beteiligte Person: | Ohishi, Mitsuru ; Ito, Norihisa ; Rakugi, Hiromi ; Yuan, Ming ; Tatara, Yuji ; Komai, Norio ; Takagi, Takashi ; Ogihara, Toshio ; Kaibe, Masaharu ; Terai, Minako |
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Zeitschrift: | American Journal of Hypertension, Jg. 18 (2005-08-01), S. 1019-1025 |
Veröffentlichung: | Oxford University Press (OUP), 2005 |
Medientyp: | unknown |
ISSN: | 0895-7061 (print) |
DOI: | 10.1016/j.amjhyper.2005.02.014 |
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