Protein Kinase D Is an Essential Regulator of C. elegans Innate Immunity
In: Immunity, Jg. 30 (2009-04-01), Heft 4, S. 521-532
Online
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Summary Protein kinase D (PKD) mediates signal transduction downstream from phospholipase C and diacylglycerol (DAG). PKDs are activated by hormones and stress in cell lines, but little is known about PKD functions and regulation in vivo. Here, we show that DKF-2, a C. elegans PKD, regulates innate immunity. Animals lacking DKF-2 were hypersensitive to killing by bacteria that are pathogens of C. elegans and humans. DKF-2 induced 85 mRNAs, which encode antimicrobial peptides and proteins that sustain intestinal epithelium. Induction of immune effector mRNAs by DKF-2 proceeded via PMK-1 (p38 Map-kinase)-dependent and -independent pathways. TPA-1, a PKCδ homolog, regulated activation and functions of DKF-2 in vivo. Therefore, DKF-2 provides a molecular link that couples DAG signaling to regulation of immunity. This intersection between DAG-TPA-1-DKF-2 and PMK-1 pathways enables integrated immune responses to multiple stimuli. Thus, a PKD mobilizes activation of host immune defenses against pathogens by previously unappreciated signaling pathways and mechanisms.
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Protein Kinase D Is an Essential Regulator of C. elegans Innate Immunity
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Autor/in / Beteiligte Person: | Feng, Hui ; Fu, Ya ; Land, Marianne ; Rubin, Charles S. ; Ren, Min |
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Zeitschrift: | Immunity, Jg. 30 (2009-04-01), Heft 4, S. 521-532 |
Veröffentlichung: | Elsevier BV, 2009 |
Medientyp: | unknown |
ISSN: | 1074-7613 (print) |
DOI: | 10.1016/j.immuni.2009.03.007 |
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