Sympathetic Overactivation in Patients With Essential Hypertension and Hepatic Iron Overload
In: Hypertension, Jg. 76 (2020-11-01), S. 1444-1450
Online
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Zugriff:
Iron overload has been recently shown to be associated with a hyperadrenergic state in genetic hemochromatosis. Whether this is also the case in essential hypertension, characterized by sympathetic activation and frequently by body iron overload, is unknown. In 17 healthy normotensive controls (age 52.3±3.2 years, mean±SE), in 21 age-matched patients with hypertension with iron overload (HT+), defined by serum ferritin levels, and in 28 hypertensives without this condition, we measured efferent postganglionic muscle sympathetic nerve traffic (microneurography), heart rate and blood pressure variability (power spectral analysis), serum ferritin, and metabolic variables. Muscle sympathetic nerve traffic was significantly ( P r =0.51, P r =0.47, P r =0.76, P r =0.46, P
| Titel: |
Sympathetic Overactivation in Patients With Essential Hypertension and Hepatic Iron Overload
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| Autor/in / Beteiligte Person: | Spaziani, Domenico ; Mancia, Giuseppe ; Airoldi, Flavio ; Quarti-Trevano, Fosca ; Bertoli, Silvio ; Seravalle, Gino ; Grassi, Guido ; Dell'Oro, Raffaella ; Seravalle, G ; Dell'Oro, R ; Quarti-Trevano, F ; Spaziani, D ; Bertoli, S ; Airoldi, F ; Mancia, G ; Grassi, G |
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| Zeitschrift: | Hypertension, Jg. 76 (2020-11-01), S. 1444-1450 |
| Veröffentlichung: | Ovid Technologies (Wolters Kluwer Health), 2020 |
| Medientyp: | unknown |
| ISSN: | 1524-4563 (print) ; 0194-911X (print) |
| DOI: | 10.1161/hypertensionaha.120.15511 |
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