A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes
In: Immunity, Jg. 41 (2014-10-01), S. 657-669
Online
unknown
Zugriff:
Autoimmune diabetes is characterized by inflammatory infiltration; however, the initiating events are poorly understood. We found that the islets of Langerhans in young nonobese diabetic (NOD) mice contained two antigen-presenting cell (APC) populations: a major macrophage and a minor CD103(+) dendritic cell (DC) population. By 4 weeks of age, CD4(+) T cells entered islets coincident with an increase in CD103(+) DCs. In order to examine the role of the CD103(+) DCs in diabetes, we examined Batf3-deficient NOD mice that lacked the CD103(+) DCs in islets and pancreatic lymph nodes. This led to a lack of autoreactive T cells in islets and, importantly, no incidence of diabetes. Additional examination revealed that presentation of major histocompatibility complex (MHC) class I epitopes in the pancreatic lymph nodes was absent with a partial impairment of MHC class II presentation. Altogether, this study reveals that CD103(+) DCs are essential for autoimmune diabetes development.
Titel: |
A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes
|
---|---|
Autor/in / Beteiligte Person: | Murphy, Kenneth M. ; Mohan, James F. ; Ferris, Stephen T. ; Unanue, Emil R. ; Carrero, Javier A. ; Calderon, Boris |
Link: | |
Zeitschrift: | Immunity, Jg. 41 (2014-10-01), S. 657-669 |
Veröffentlichung: | Elsevier BV, 2014 |
Medientyp: | unknown |
ISSN: | 1074-7613 (print) |
DOI: | 10.1016/j.immuni.2014.09.012 |
Schlagwort: |
|
Sonstiges: |
|