OCT4 expression transactivated by GATA protein is essential for non-rodent trophectoderm early development
In: Cell reports, Jg. 41 (2021-12-13), Heft 8
Online
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Zugriff:
Oct4 is exclusively expressed in rodent inner cell mass (ICM) but silenced in its trophectoderm (TE). However, for many non-rodent animals, including pig, cattle, rabbit, goat, and human, OCT4 has a remarkable expression in early TE. This study, applying pig as the main research model, proves that OCT4 expression in TE is supported by a unique GATA motif in the OCT4 upstream conserved regulatory region, and GATA4 is responsible for its activation. Moreover, OCT4 acts as a specific regulator of a narrow range of genes (including BCL2A1 and HNRNP2AB1) that are essential for the first wave of rapid proliferation in early TE. This study describes the regulatory mechanism to direct the OCT4 expression and its significance in TE of porcine preimplantation embryo.
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OCT4 expression transactivated by GATA protein is essential for non-rodent trophectoderm early development
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| Autor/in / Beteiligte Person: | Bou, Gerelchimeg ; Guo, Jia ; Liu, Shichao ; Guo, Shimeng ; Davaakhuu, Gantulga ; Lv, Qi ; Xue, Binghua ; Qiao, Shupei ; Lv, Jiawei ; Weng, Xiaogang ; Zhao, Jianchao ; Zhang, Yuting ; He, Yilong ; Zhang, Heng ; Chai, Zhuang ; Liu, Yan ; Yu, Yanbo ; Qu, Bo ; Sun, Ruizhen ; Shen, Xinghui ; Lei, Lei ; Liu, Zhonghua |
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| Zeitschrift: | Cell reports, Jg. 41 (2021-12-13), Heft 8 |
| Veröffentlichung: | 2021 |
| Medientyp: | unknown |
| ISSN: | 2211-1247 (print) |
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