The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass
In: Scientific reports, Jg. 7 (2017-01-12)
Online
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Zugriff:
The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7−/− mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also significantly increased the serum osteoprotegerin/RANKL ratio, and elevated bone mass seen in nAchR7−/− mice was reversed in α7nAchR/osteoprotegerin-doubly-deficient mice. α7nAchR loss significantly increased TNFα expression in Mac1-positive macrophages, and TNFα increased the osteoprotegerin/RANKL ratio in osteoblasts. Targeting TNFα in nAchR7−/− mice normalized both serum osteoprotegerin/RANKL ratios and bone mass. Administration of nicotine, an α7nAchR ligand, to wild-type mice increased serum RANKL levels. Thus, vagal nerve stimulation of macrophages via α7nAchR regulates bone mass by modulating osteoclast formation.
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The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass
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Autor/in / Beteiligte Person: | Iwama, Atsushi ; Mito, Kazuaki ; Matsumoto, Morio ; Miyamoto, Takeshi ; Miyamoto, Kana ; Kobayashi, Tami ; Nakamura, Masaya ; Nitta, Eriko ; Sato, Kazuki ; Sato, Yuiko |
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Zeitschrift: | Scientific reports, Jg. 7 (2017-01-12) |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 2045-2322 (print) |
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