The β‐turn‐supporting motif in the polyglutamine binding peptide QBP1 is essential for inhibiting huntingtin aggregation
In: FEBS Letters, Jg. 594 (2020-07-11), S. 2894-2903
Online
unknown
Zugriff:
Aggregation of polyglutamine proteins is a hallmark of several neurodegenerative diseases. The 11-residue polyglutamine binding peptide Ac-SNWKWWPGIFD-am, known as QBP1, inhibits polyglutamine aggregation. Besides, a minimal 8-residue stretch in the QBP1 peptide (Ac-WKWWPGIF-am) is reported in the literature to retain this activity. Both peptides harbor a Pro-Gly dipeptide motif, a feature characteristic of potential β-turn regions. Here, we investigated whether the presence of this β-turn motif is necessary for the inhibition of huntingtin aggregation, a polyglutamine protein implicated in Huntington's disease. Using single amino acid substitutions to generate analogs that could support, introduce, or eliminate the β-turn, we show that the turn-supporting motif is essential for QBP1-mediated inhibition of huntingtin aggregation.
Titel: |
The β‐turn‐supporting motif in the polyglutamine binding peptide QBP1 is essential for inhibiting huntingtin aggregation
|
---|---|
Autor/in / Beteiligte Person: | Chaudhary, Nitin ; Datta, Debika ; Vinay Kumar Belwal |
Link: | |
Zeitschrift: | FEBS Letters, Jg. 594 (2020-07-11), S. 2894-2903 |
Veröffentlichung: | Wiley, 2020 |
Medientyp: | unknown |
ISSN: | 1873-3468 (print) ; 0014-5793 (print) |
DOI: | 10.1002/1873-3468.13873 |
Schlagwort: |
|
Sonstiges: |
|