Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil
In: Revista Brasileira de Farmacognosia, Volume: 22, Issue: 2, Pages: 443-450, Published: 06 JAN 2012 Revista Brasileira de Farmacognosia, Jg. 22 (2012), Heft 2, S. 443-450
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Zugriff:
Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19.57%), E-isovalencenol (13.24%), α-vetivone (5.25%), β-vetivone (4.87%) and hydroxy-valencene (4.64%). Following intraperitoneal injection (i.p.), EO at 50 and 100 mg/kg significantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. However, EO-treated mice were ineffective at all doses in hot-plate and rota-rod tests. The EO inhibited the carrageenan-induced leukocyte migration to the peritoneal cavity in a dose-dependent manner (34.7, 35.4, and 62.5% at doses of 25, 50 and 100 mg/kg, respectively). In the paw edema test, the EO (100 mg/kg) inhibited all three phases of the edema equally well, suggesting that the EO has a non-selective inhibitory effect on the release or actions of these mediators. Our results suggest possible antinociceptive and anti-inflammatory effects of the EO.
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Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil
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Autor/in / Beteiligte Person: | José Cláudio Fonseca Moreira ; Julianeli Tolentino de Lima ; Ricardo Fagundes da Rocha ; Daniel Pens Gelain ; Gabrielle Mendes Lima ; Mônica Santos de Melo ; Lucindo José Quintans-Júnior ; Adriano Antunes De Souza Araújo ; Thomazzi, Sara M. ; Arie Fitzgerald Blank ; Paulina Marques de Oliveira Neta ; Mairim Russo Serafini ; Péricles Barreto Alves ; Emyle Mayra Santana Alves Almeida ; Sócrates Cabral de Holanda Cavalcanti ; João Paulo Almeida dos Santos |
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Zeitschrift: | Revista Brasileira de Farmacognosia, Volume: 22, Issue: 2, Pages: 443-450, Published: 06 JAN 2012 Revista Brasileira de Farmacognosia, Jg. 22 (2012), Heft 2, S. 443-450 |
Veröffentlichung: | Sociedade Brasileira de Farmacognosia, 2012 |
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