Irisin levels in genetic and essential obesity: clues for a potential dual role
In: Scientific Reports Scientific Reports, Jg. 10 (2020), Heft 1, S. 1-9
Online
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Zugriff:
Irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. Its potential link to fat accumulation and metabolic dysfunction is debated. We sought to explore the relationship between circulating irisin and components of body composition in two different phenotypes of severe obesity. For this purpose, 30 obese adults with Prader-Will syndrome (PWS) (age 35.7 ± 1.5 y, BMI 45.5 ± 1.5 kg/m2) and 30 adult controls with common obesity (age 34.9 ± 1.7 y, BMI 46.8 ± 1.4 kg/m2) underwent analysis of irisin levels, metabolic profile, body composition and resting energy expenditure (REE). Normal irisin levels were obtained from a group of 20 lean donors (age 32.4 ± 1.5 y, BMI 23.8 ± 0.8 kg/m2). Expected differences in body composition and metabolic profile existed between study groups. PWS exhibited lower muscle mass (p
| Titel: |
Irisin levels in genetic and essential obesity: clues for a potential dual role
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| Autor/in / Beteiligte Person: | Mai, Stefania ; Vietti, Roberta ; Aimaretti, Gianluca ; Sartorio, Alessandro ; Scacchi, Massimo ; Mele, Chiara ; Marzullo, Paolo ; Grugni, Graziano ; Vigna, Luisella |
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| Zeitschrift: | Scientific Reports Scientific Reports, Jg. 10 (2020), Heft 1, S. 1-9 |
| Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
| Medientyp: | unknown |
| ISSN: | 2045-2322 (print) |
| DOI: | 10.1038/s41598-020-57855-5 |
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