Chemical composition and α-amylase inhibitory activity of the essential oil from Sabina chinensis cv. Kaizuca leaves
In: Natural product research, Jg. 32 (2017-05-26), Heft 6
Online
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Zugriff:
Sabina chinensis cv. Kaizuca (SCK) is a variant of S. chinensis L. The essential oil from its leaves exhibited α-amylase inhibitory activity in vitro and the IC50 value was 187.08 ± 0.56 μg/mL. Nineteen compounds were identified from this essential oil by gas chromatography–mass spectrometry (GC-MS) analysis. The major compounds identified were bornyl acetate (42.6%), elemol (20.5%), β-myrcene (13.7%) and β-linalool (4.0%). In order to study the reason of the α-amylase inhibitory activity of this essential oil, the identified compounds were docked with α-amylase by molecular docking individually. Among these compounds, γ-eudesmol exhibited the lowest binding energy (−6.73 kcal/mol), followed by α-copaen-11-ol (−6.66 kcal/mol), cubedol (−6.39 kcal/mol) and α-acorenol (−6.12 kcal/mol). The results indicated that these compounds were the active ingredients responsible for the α-amylase inhibitory activity of essential oil from SCK.
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Chemical composition and α-amylase inhibitory activity of the essential oil from Sabina chinensis cv. Kaizuca leaves
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Autor/in / Beteiligte Person: | Liu, Hengming ; Fang, Chen ; Yang, Jiao ; Yang, Yi ; Minjing, Li ; Gu, Dongyu |
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Zeitschrift: | Natural product research, Jg. 32 (2017-05-26), Heft 6 |
Veröffentlichung: | 2017 |
Medientyp: | unknown |
ISSN: | 1478-6427 (print) |
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