Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure
In: FASEB Journal FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩ Nicolaisen, T S, Klein, A B, Dmytriyeva, O, Lund, J, Ingerslev, L R, Fritzen, A M, Carl, C S, Lundsgaard, A, Frost, M, Ma, T, Schjerling, P, Gerhart-Hines, Z, Flamant, F, Gauthier, K, Larsen, S, Richter, E A, Kiens, B & Clemmensen, C 2020, ' Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure ', F A S E B Journal, vol. 34, no. 11, pp. 15480-15491 https://doi.org/10.1096/fj.202001258RR The FASEB Journal FASEB Journal, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩; (2020-11-01) S. 15480-15491
Online
unknown
Zugriff:
Thyroid hormones are important for homeostatic control of energy metabolism and body temperature. Although skeletal muscle is considered a key site for thyroid action, the contribution of thyroid hormone receptor signaling in muscle to whole-body energy metabolism and body temperature has not been resolved. Here, we show that T3-induced increase in energy expenditure requires thyroid hormone receptor alpha 1 (TRα1 ) in skeletal muscle, but that T3-mediated elevation in body temperature is achieved in the absence of muscle-TRα1 . In slow-twitch soleus muscle, loss-of-function of TRα1 (TRαHSACre ) alters the fiber-type composition toward a more oxidative phenotype. The change in fiber-type composition, however, does not influence the running capacity or motivation to run. RNA-sequencing of soleus muscle from WT mice and TRαHSACre mice revealed differentiated transcriptional regulation of genes associated with muscle thermogenesis, such as sarcolipin and UCP3, providing molecular clues pertaining to the mechanistic underpinnings of TRα1-linked control of whole-body metabolic rate. Together, this work establishes a fundamental role for skeletal muscle in T3-stimulated increase in whole-body energy expenditure.
Titel: |
Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure
|
---|---|
Autor/in / Beteiligte Person: | Gerhart-Hines, Zachary ; Klein, Anders B. ; Fritzen, Andreas M. ; Clemmensen, Christoffer ; Lundsgaard, Anne-Marie ; Larsen, Steen ; Dmytriyeva, Oksana ; Ingerslev, Lars R. ; Flamant, Frédéric ; Ma, Tao ; Gauthier, Karine ; Frost, Mikkel ; Carl, Christian S. ; Schjerling, Peter ; Richter, Erik A. ; Kiens, Bente ; Nicolaisen, Trine S. ; Lund, Jens ; Inflammasome NLRP3 – NLRP3 Inflammasome ; Centre International de Recherche en Infectiologie - UMR (CIRI) ; École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Centre International de Recherche en Infectiologie (CIRI) ; École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
Link: | |
Quelle: | FASEB Journal FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩ Nicolaisen, T S, Klein, A B, Dmytriyeva, O, Lund, J, Ingerslev, L R, Fritzen, A M, Carl, C S, Lundsgaard, A, Frost, M, Ma, T, Schjerling, P, Gerhart-Hines, Z, Flamant, F, Gauthier, K, Larsen, S, Richter, E A, Kiens, B & Clemmensen, C 2020, ' Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure ', F A S E B Journal, vol. 34, no. 11, pp. 15480-15491 https://doi.org/10.1096/fj.202001258RR The FASEB Journal FASEB Journal, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩; (2020-11-01) S. 15480-15491 |
Veröffentlichung: | HAL CCSD, 2020 |
Medientyp: | unknown |
ISSN: | 0892-6638 (print) ; 1530-6860 (print) |
Schlagwort: |
|
Sonstiges: |
|