Comparison of lisinopril versus atenolol for mild to moderate essential hypertension
In: The American Journal of Cardiology, Jg. 67 (1991), S. 59-62
Online
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Zugriff:
The antihypertensive effects and safety profiles of lisinopril (10 to 40 mg) and atenolol (50 to 100 mg) were compared in a randomized, double-blind, parallel group trial in 144 patients with essential hypertension. After 8 weeks of therapy, seated blood pressure (BP) decreased by 26/15 mm Hg with lisinopril and by 19/14 mm Hg with atenolol. Lisinopril produced a greater reduction (p less than 0.05) in sitting systolic BP than did atenolol. Standing BP decreased by 25/15 mm Hg with lisinopril and by 19/14 mm Hg with atenolol. No important changes in hematologic and biochemical profiles were seen with either drug. Eleven patients, 7 receiving lisinopril and 4 receiving atenolol, were withdrawn because of adverse experiences; another 3 patients defaulted during treatment, 1 in the lisinopril group and 2 in the atenolol group. Both drugs were well-tolerated and are therefore suitable for first-line therapy in essential hypertension.
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Comparison of lisinopril versus atenolol for mild to moderate essential hypertension
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Autor/in / Beteiligte Person: | Garnham, Simon ; Kumar, Shubna ; Feely, Morgan ; Husaini, Murtaza H. ; Blackwood, Roger A. ; Connett, Carol ; Watson, Michael S. ; Long, Christine ; Angell-James, Jennifer E. ; Mannering, D. ; D. Gareth Beevers ; Admani, Karim ; Mehrzad, Abdul A. |
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Zeitschrift: | The American Journal of Cardiology, Jg. 67 (1991), S. 59-62 |
Veröffentlichung: | Elsevier BV, 1991 |
Medientyp: | unknown |
ISSN: | 0002-9149 (print) |
DOI: | 10.1016/0002-9149(91)90100-y |
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