Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice
In: Cell Death and Disease, Jg. 12 (2021), Heft 6, S. 1-16
Online
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Zugriff:
Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels. However, nothing is known for the role of Kindlin-2 in mesoderm-derived reproductive organs. Here, we report that loss of Kindlin-2 in Sertoli cells caused severe testis hypoplasia, abnormal germ cell development and complete infertility in male mice. Functionally, loss of Kindlin-2 inhibits proliferation, increases apoptosis, impairs phagocytosis in Sertoli cells and destroyed the integration of blood-testis barrier structure in testes. Mechanistically, Kindlin-2 interacts with LATS1 and YAP, the key components of Hippo pathway. Kindlin-2 impedes LATS1 interaction with YAP, and depletion of Kindlin-2 enhances LATS1 interaction with YAP, increases YAP phosphorylation and decreases its nuclear translocation. For clinical relevance, lower Kindlin-2 expression and decreased nucleus localization of YAP was found in SCOS patients. Collectively, we demonstrated that Kindlin-2 in Sertoli cells is essential for sperm development and male reproduction.
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Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice
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Autor/in / Beteiligte Person: | Zhang, Hongquan ; Li, Bing ; Zhan, Jun ; Chi, Xiaochun ; Yu, Miao ; Wang, Zhenbin ; Luo, Weiwei ; Su, Tiantian ; Liu, Cheng ; Song, Jiagui ; He, Hui-ying ; Wang, Tianzhuo ; Li, Zhen |
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Zeitschrift: | Cell Death and Disease, Jg. 12 (2021), Heft 6, S. 1-16 |
Veröffentlichung: | Nature Publishing Group, 2021 |
Medientyp: | unknown |
ISSN: | 2041-4889 (print) |
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