DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
In: eLife eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.61769⟩ eLife, Vol 10 (2021) eLife, 2021, 10, ⟨10.7554/eLife.61769⟩; (2021-04-19)
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Zugriff:
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). DCC and NTN1 are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in Dcc and Ntn1 knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with DCC mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it.
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DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
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Autor/in / Beteiligte Person: | Lockhart, Paul J. ; Chédotal, Alain ; Shaikh, Samreen ; Fothergill, Thomas ; Zagar, Yvrick ; Kozulin, Peter ; Leventer, Richard J. ; Fenlon, Laura R. ; Suárez, Rodrigo ; Cooper, Helen M. ; Ye, Yunan ; Morcom, Laura ; Bridges, Caitlin ; Gobius, Ilan ; Sherr, Elliott H. ; Richards, Linda J. ; Edwards, Timothy J. ; Amber Lee Skye Donahoo ; Douglass, Amelia M. ; Ashley P L Marsh ; Lim, Jonathan W. C. ; University of Queensland [Brisbane] ; Institut de la Vision ; Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; University of California [San Francisco] (UCSF) ; University of California ; Gestionnaire, Hal Sorbonne Université ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; University of California [San Francisco] (UC San Francisco) ; University of California (UC) |
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Quelle: | eLife eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.61769⟩ eLife, Vol 10 (2021) eLife, 2021, 10, ⟨10.7554/eLife.61769⟩; (2021-04-19) |
Veröffentlichung: | HAL CCSD, 2021 |
Medientyp: | unknown |
ISSN: | 2050-084X (print) |
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